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Understanding DMSO Use in Equine Veterinary Medicine

A complex history reveals its evolving role in horse care

April 7, 2025 at 2:17 PMBy b.wehner

Understanding DMSO Use in Equine Veterinary Medicine

Dimethyl sulfoxide (DMSO), a viscous liquid with a strong odor, is often encountered in equestrian settings due to its application in treating a variety of health issues in horses. Initially derived from the byproducts of paper manufacturing, DMSO was once viewed as a miracle solution in the 1960s. However, its use diminished amid safety concerns before regaining acceptance following regulatory approval for equine use in 1970. DMSO is noted not just for treating specific ailments, but for offering an innovative therapeutic approach that enhances the effectiveness of various treatments, as explained by experts such as Barney Fleming, DVM, and Stanley W. Jacob, MD.


While DMSO is generally safe, it must be administered carefully due to its potent effects and ability to interact dynamically with other substances. Veterinarians recommend using DMSO under medical guidance to mitigate potential risks. The chemical's ability to penetrate cell membranes and its interactions with water molecules contribute to its versatility in treating inflammatory conditions, including applications for musculoskeletal injuries, laminitis, and neurological issues. DMSO is often combined with other medications to boost their effectiveness, yet caution is necessary as it can also enhance the absorption of harmful substances. The importance of proper dosage and cautious application is underscored by concerns over adverse reactions when combined with certain medications. Overall, DMSO stands as a unique component in the toolkit of equine care, enhancing therapeutic outcomes when utilized responsibly.

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